Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma (twitter.com)

Article summary

Moderna and Merck have announced positive Phase 3 results for an individualized mRNA therapy for melanoma, in combination with KEYTRUDA, in patients with completely resected stage IIB-IV melanoma. The study met its primary endpoint of recurrence-free survival and a key secondary endpoint of distant metastasis-free survival. This is the first positive Phase 3 result for an individualized neoantigen therapy and the first for an mRNA-based cancer therapy. The results mark an important milestone for Moderna and the field of mRNA therapy.

Main themes

• mRNA therapy
• melanoma treatment
• sun exposure
• skin cancer
• historical context
• personal experiences

What commenters say

• Some people believe that historical warnings about sun exposure were driven by fashion and class, rather than a fundamental understanding of damaging UV exposure.
• Others argue that people have always known that too much sun is bad for you, and that this knowledge was not necessarily linked to an understanding of skin cancer.
• There is a disagreement about the relationship between melanoma and sun exposure, with some arguing that it is weaker than for other types of skin cancer.
• The use of sunscreen and its potential health effects are also a topic of discussion, with some expressing concerns about the ingredients in sunscreen and others arguing that it is a necessary precaution.
• Some commenters share personal experiences of getting sunburned despite taking precautions, while others argue that building up a tan can provide protection against sunburn.
• The historical context of sun exposure and skin cancer is also discussed, with some referencing the practice of heliotherapy and the use of sun exposure as a treatment for various diseases.
• There is also a discussion about the importance of understanding the science behind sun exposure and skin cancer, and not relying on anecdotal evidence or misinformation.
• The role of melanin in protecting against sunburn is also debated, with some arguing that it provides significant protection and others arguing that it is not a guarantee against sunburn or skin damage.