The Rough-Skinned Newt is a highly toxic species native to the Pacific Northwest, with a poison that can kill several adult humans. The newt's toxicity is part of an evolutionary arms race with the common garter snake, which has developed resistance to the newt's poison. The snakes sequester the toxin and use it for their own defense, creating a feedback loop where the newts evolve to be more toxic and the snakes evolve to be more resistant. This arms race has significant costs for both species, including metabolic loads and potential negative effects on the snakes' nervous systems.