The wood frog has a unique adaptation to survive the harsh winter conditions in the northern forests of Alaska and Canada, where temperatures can drop to -80 degrees Fahrenheit. During hibernation, the frog's body freezes, with ice forming in its abdominal cavity and around its organs, but its cells are protected from freezing by a syrupy sugar solution produced by its liver. This adaptation allows the frog to survive for up to eight months without eating, drinking, or breathing, and to thaw out in the spring when temperatures rise. The wood frog's ability to withstand freezing may have implications for human medicine, particularly in the management of high blood sugar and the preservation of organs for transplantation.