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First 'tooth regrowth' medicine moves toward clinical trials in Japan (mainichi.jp)

970 points by elorant · 1152 days ago · 299 comments on HN

Article summary

A Japanese research team is developing a medicine that may allow people to grow new teeth, with clinical trials set to begin in July 2024. The medicine is intended for people who lack a full set of adult teeth due to congenital factors, such as anodontia. The team aims to have the medicine ready for general use by 2030. The medicine works by blocking a protein called USAG-1, which limits tooth growth.

Main themes

  • tooth regrowth medicine
  • anodontia
  • dental implants
  • congenital tooth loss
  • stem cell research
  • regenerative medicine
  • dental health

What commenters say

  • Some commenters are skeptical about the potential of the medicine to replace dental implants and dentures.
  • Others believe that the medicine could be a game-changer for people with congenital tooth loss, but may not be suitable for those who have already received implants.
  • There is discussion about the potential for the medicine to be used to grow replacement teeth in a laboratory and then transplant them into the patient.
  • Some commenters share their personal experiences with tooth loss and dental implants, and express interest in the potential of the medicine to improve their quality of life.
  • The possibility of using the medicine to stimulate continuous tooth growth, similar to some animals, is also discussed.
  • Some commenters note that the medicine is still in the early stages of development and may not be available for many years.
  • There is also discussion about the potential risks and benefits of the medicine, including the possibility of cancer or other adverse effects.