Per- and polyfluoroalkyl substances (PFAS) are hazardous chemicals that have been found in rainwater and snow globally, including in remote locations like Antarctica and the Tibetan plateau. The levels of PFAS in environmental media are now above guideline levels, making rainwater unsafe to drink. Researchers suggest that PFAS have exceeded a new planetary boundary for novel entities. The persistence and global cycling of PFAS will continue to exceed environmental quality guidelines designed to protect human health.